ANTI-INFLAMMATORY PROTECTION

Inflammation is a natural process by which the body promotes healing, and protects itself against damage caused by injury, infection, free radicals and foreign substances. There are however many risk factors, as those mentioned above, that chronically induce inflammation, and persistently promote infiltration of inflammatory agents into the joints. If not controlled, these agents cause constant swelling, pain, and eventually degeneration of joint tissue.  Consequently, arthritis sets in, with a debilitating effect on mobility, performance and well-being.

CURCUMIN 95% extract (Curcuma longa) is a highly concentrated constituent (32 times stronger than turmeric powder) extracted from turmeric, and one of the most researched, and effective anti-inflammatory plant extracts.  Curcumin reduces inflammation by multiple mechanisms like inhibiting pro-inflammatory signalling, inhibiting immune cell migration to the active site of inflammation, and reducing excessive existing inflammation by decreasing the activity of inflammatory enzymes1-7. Curcumin illustrates pronounced potential to reduce joint pain, enhance articular function, and improve quality of movement10-12.

BOSWELIA (Boswellia serrata) is a powerful anti-inflammatory plant extract.  It demonstrates pronounced clinical efficiency in the treatment of painful inflammatory conditions like muscle injuries, arthritic diseases.    Boswellia’s mechanisms of action in arthritic treatment include: inhibition of inflammatory agents, improvement of blood circulation to the joints, alleviation of pain, and decreased joint swelling.  In contrast to non-steroidal anti-inflammatory drugs (NSAIDS) which disrupt glycosaminoglycan synthesis, Boswellia inhibits inflammation-induced degeneration of glycosaminoglycans levels, supporting the structural strength of the joints. 30,31 Research validates that Boswellia can significantly improve joint flexibility and mobility32.

MSM (Methylsulfonylmethane) significantly reduces inflammation and pain in various joint conditions. It works by inhibiting inflammatory cytokines and oxidative stress, thereby providing relief from joint pain and improving mobility. Research indicates that MSM significantly reduces pain and inflammation caused by osteoarthritis and rheumatoid arthritis, enhancing overall joint function and quality of life 33-41.

Omega-3 fatty acids exhibit potent anti-inflammatory effects by modulating the production of pro-inflammatory eicosanoids and cytokines. They help reduce joint inflammation and pain, making them beneficial for managing rheumatoid arthritis and other inflammatory joint diseases. Omega-3s contribute to decreased joint stiffness and improved mobility 42-43.

Collagen, particularly type II collagen, has been shown to modulate immune responses and reduce inflammation in the joints. It helps inhibit the breakdown of cartilage and significantly reduces joint pain associated with conditions like rheumatoid arthritis and osteoarthritis in dogs and cats. Collagen supplementation has been linked to significant improvements in joint function and pain relief. 28-29,44

HEALTHY CARTILAGE and STRUCTURAL SUPPORT

During ageing or reduced activity, muscle mass and strength decline, and body weight may unhealthily increase.  This predisposes the animal to decreased joint stability and misalignment.  Consequently, with increased mechanical stress, degenerative inflammation sets in, deteriorating cartilage and joints.

CURCUMIN is well researched for its powerful anti-inflammatory actions.  And with its protective properties on cartilage8, it has exceptional medical value in the treatment of arthritic diseases. Research shows that highly concentrated curcumin extract stimulates the production of glycosaminoglycans, chondrocytes, and type II collagen which are involved in the formation and structural integrity of cartilage9.  It also inhibits inflammation-induced degeneration of cartilage and chondrocytes13,14.  Curcumin further inhibits joint inflammation and joint destruction by inhibiting bone resorption osteoclast cells, and blocking expression of genes, inflammatory enzymes like COX-2, and other inflammatory mediators that promotes joint degeneration25.

GLUCOSAMINE SULPHATE is a superior form of glucosamine due to its enhanced bio-availability. It consists of a structural amino acid, glucosamine, which is abundantly found in joint cartilage, synovial fluid in the joints, and in the intervertebral discs.   It also contains Sulphur which is required by every cell in the body for efficient function.  Sulphur is a vital element for healthy connective tissues, it is utilized in detoxification of toxins, is involved in cellular respiration, promotes healing, and helps to relieve symptoms of arthritis. Research illustrates that Glucosamine Sulphate’s efficacy is superior to Chondroitin Sulphate in arthritic conditions. It has a growth-promoting effect on cartilage, and delays cartilage degeneration by various effective antioxidant and anti-inflammatory mechanisms. Studies conclude that long term supplementation with Glucosamine Sulphate clinically benefits arthritis sufferers by reducing pain, reducing arthritis progression, enhancing joint function and mobility, and decreasing the risk of total joint replacement.15

COLLAGEN supplementation has been shown to support cartilage regeneration and improve joint structure. Type II collagen provides essential building blocks for cartilage repair and maintenance, enhancing joint strength and reducing symptoms of cartilage degeneration.44-48

MSM (Methylsulfonylmethane) supports cartilage health by promoting collagen synthesis and reducing joint degradation. It has been shown to improve joint flexibility and prevent further cartilage damage. MSM supplementation aids in the maintenance of cartilage integrity and overall joint health.49-51

OMEGA-3 FATTY ACIDS support cartilage health by reducing inflammation and promoting the synthesis of cartilage matrix components. They help maintain joint integrity and reduce cartilage breakdown, which is crucial for preventing degenerative joint disease.53

IMMUNE MODULATION

The immune system is a complex defence system against foreign substances and pathogenic microorganisms.  The immune system produces antibodies from B lymphocytes (white blood cells), which bind to, and destroy invading organisms.  These antibodies are stored in the body to recognize, and destroy a recurring pathogen more effectively during follow up invasion.  T lymphocytes destroy invading pathogens by releasing toxic chemicals. They also release messenger chemicals to attract macrophagic white blood cells which engulf and kill pathogens.  T lymphocytes regulate immune responsiveness to specific agents, and can be divided into Th1 and Th2 cells.  Th1 cells are proposed to mostly mediate immune protection against intracellular viruses and certain bacteria, destroy cancerous cells, and activate delayed hypersensitivity skin reactions. Th2 cells mediate immune protection against extracellular bacteria, parasites, allergens, and toxins. Immune dysfunction and overexpression of Th1 cells may result in a proinflammatory state and organ specific autoimmunity.  Overexpression of Th2 is indicated in systemic autoimmunity and chronic allergy related conditions. 

CURCUMIN regulates Th1 and Th2 immune responses, as well as production of inflammatory mediators.  By modulating immune function and inhibiting inflammation, Curcumin demonstrates marked clinical efficacy in the treatment of osteo- and rheumatoid arthritis26,27,49,51. 

OMEGA-3S play a significant role in modulating the immune system by reducing the production of inflammatory cytokines and enhancing anti-inflammatory responses. They contribute to a balanced immune response, which is beneficial for managing autoimmune and inflammatory joint conditions. 54-55

MSM modulates immune function by reducing inflammatory responses and enhancing the body’s ability to manage autoimmune conditions. It helps alleviate symptoms of immune-mediated joint diseases by reducing inflammation and supporting overall immune health.56

COLLAGEN helps modulate immune responses by reducing the production of inflammatory mediators and promoting a balanced immune response. Type II collagen, in particular, has been found to alleviate symptoms of autoimmune joint diseases by enhancing immune tolerance and reducing joint inflammation 57

BOSWELLIA SERRATA extracts and boswellic acids have significant immune-modulating properties that can benefit joint health, particularly in the context of inflammatory joint diseases. According to the study by Ammon HP, these compounds influence the immune system by modulating various cellular and molecular pathways involved in inflammation. Specifically, Boswellia serrata extracts inhibit the production of pro-inflammatory cytokines, which are key drivers of inflammation in joint diseases such as arthritis. Additionally, boswellic acids suppress the activation of immune cells like T lymphocytes and macrophages that contribute to the chronic inflammatory response in joints. By dampening the immune system’s overactive response, Boswellia serrata helps reduce inflammation, pain, and tissue damage associated with joint diseases, thereby promoting better joint function and mobility.95

ADDITIONAL BENEFITS TO OVERALL HEALTH & WELL-BEING

Untamed Hip & Joint GOLD further benefits multiple physiological systems to enhance your pet’s health to a completely new level. 

Turmeric is a highly valued medicinal herb. Owing to CURCUMIN, its active constituent, it has been used for thousands of years for its remarkable medicinal benefits. Unfortunately, turmeric is not absorbed very well, and one has to take a large amount of turmeric powder to be of systemic benefit.  Hence the production of 95% Turmeric extract which provides pure curcumin, with higher medicinal significance in the body.  

Actions and health benefits of Curcumin 58-92

• Antiallergenic: Turmeric is well known as an immunomodulatory herb. Curcumin alleviates symptoms associated with allergic immune responses by regulating Th-1(inflammatory) and Th-2 cytokine (autoimmunity/allergy) responses, inhibiting IgE levels, and inhibiting mast cell degranulation which releases histamine.  These properties give curcumin great potential for clinical management of allergic reactions like asthma, food allergies and allergy related skin conditions. 
• Antimicrobial:  Curcumin provides broad-spectrum antimicrobial protection against bacteria like Staphylococcus epidermis, Staphylococcus aureus, Klebsiela pneumoniae, Helicobacter pylori,  Escherichia coli, Salmonella and many others; viruses like influenza viruses, herpes, coxsackie, hepatitis viruses, papilloma viruses, encephalitis viruses and many more; fungi like Cryptococcus neoformans, Candida albicans, and other skin fungi like T rubrum, T. mentagrophytes, E. floccosum and M. gypseum, and parasites Schistosomas, Toxocara canis, Eimeria species, Plasmodium, Trypanosoma, Giardia lamblia, Leishmania and Cryptosporidium. 
• Powerful anti-inflammatory and antioxidant:  Curcumin reduces inflammation by multiple mechanisms like inhibiting pro-inflammatory signalling, inhibiting immune cell migration to the active site of inflammation, and reducing excessive existing inflammation by decreasing the activity of inflammatory enzymes.
• Neuroprotective:  Curcumin can protect nerve cells against inflammation and degeneration caused by multiple pathological agents including toxins, stress related high cortisol levels, and age-related degenerative conditions like Alzheimer’s and Parkinson’s disease.
• Protect against heart disease:  Curcumin provides protection against cardiac hypertrophy, inflammation, atherosclerosis, blood clot formation and high cholesterol.
• Antidiabetic: Curcumin illustrates promising protection against insulin resistance, diabetes and its associated inflammatory pathways.
• Antiarthritic:  Curcumin is well researched for its powerful anti-inflammatory actions which, in addition to its protective properties on cartilage, adds exceptional medical value to this plant extract for the treatment of arthritic diseases. Research shows that a highly-concentrated curcumin extract stimulates the production of glycosaminoglycans and chondrocytes, which are involved in the formation and structural integrity of cartilage.  Curcumin supplementation can reduce joint pain, enhance articular function, and improve quality of movement.
• Anticancer:  Research illustrates that high dose of concentrated Curcumin extract can inhibit the growth of various cancers and enhance the anticancer effects of chemotherapy drugs and radiation.  Curcumin, may alleviate the risk of cancer by supporting the natural defence mechanisms of a mammal by increasing antioxidant protection, inhibiting inflammatory degeneration, enhancing liver detoxification by down-regulating Phase I and enhancing Phase II detoxification of cancer-causing agents like cigarette smoke, benzopyrene, and DMBA, and inhibiting cancer cell development and spreading.
• Accelerates wound healing: Curcumin exerts a significant wound healing effect owing to its anti-oxidant, anti-inflammatory, anti-infectious, and immune-modulating characteristics. Curcumin targets various stages of wound healing. It promotes the removal of dead tissue from the site of injury, formation of new blood vessels in that area, granulation tissue, deposition of collagen for increased tissue strength and integrity, and wound closure.
• Enhances skeletal muscle repair: Soft tissue injury is most often related to a sport injury.  The results are swelling, bruising, severe pain, and ultimately diminished muscle function & performance.  The repair process involves tissue degeneration, inflammation, regeneration, and scar tissue formation.  Curcumin promotes healthy muscle repair by supporting balanced and efficient anti-inflammatory-, immune- and anti-oxidant responses, which enhances muscle cell regeneration and accelerates recovery. By modulating inflammation, reducing lactate accumulation and reducing pain following intensive exercise, curcumin facilitates a faster return to training and increases the capacity for higher training intensity.
• Supports healthy digestive function: Curcumin provides significant anti-inflammatory protection in the digestive tract, alleviating inflammatory damage, abdominal pain and gastric discomfort associated with IBS (irritable bowel syndrome), ulcerative colitis, Crohn’s disease and H. pylori- induced ulcers.

BOSWELLIA

Boswellic acid, a constituent of Boswellia, has potent anti-inflammatory, expectorant, antiseptic, pain-relieving, antibacterial, anti-anxiety, and anti-neurotic properties.  Clinical studies indicate that Boswellic acids have the ability to modulate many mediators involved in disease progression. It exhibits clinical efficacy in the treatment of conditions like93-95:

• Arthritis, 

• Alzheimer’s Disease, 

• Asthma, Bronchitis, Sinusitis,

• Various Cancers and Tumours, 

• Cognitive Impairment, and Central Nervous System Disorders

• Atherosclerosis, 

• Inflammatory Bowel Disease, Ulcerative Colitis & Irritable Bowel Syndrome,

• Diabetes, 

• Psoriasis.

COLLAGEN Type II
The health benefits of collagen, particularly derived from cartilage, include 98:

• Joint Health Support: Collagen provides essential amino acids that are vital for the maintenance and repair of joint cartilage, enhancing overall joint health and flexibility.
• Osteoarthritis Relief: Supplementation with collagen has been shown to reduce joint pain and stiffness in individuals with osteoarthritis, by supporting cartilage regeneration and reducing inflammation.
• Rheumatoid Arthritis Management: Collagen helps in managing rheumatoid arthritis by modulating the immune system, reducing inflammation, and slowing down the progression of joint degradation.
• Bone Health: Collagen supports the structural integrity of bones, improving bone mineral density and reducing the risk of fractures.
• Skin and Connective Tissue Health: Beyond joint benefits, collagen enhances skin elasticity, hydration, and the overall strength of connective tissues, contributing to healthier skin and reduced signs of aging.

Omega-3 Fatty Acids 99-103

The health benefits of omega-3 fatty acids, as highlighted in the research by Qin et al. (2023), include:

• Cardiovascular Health: Omega-3 fatty acids help reduce the risk of cardiovascular diseases by lowering blood pressure, reducing triglycerides, and preventing arterial plaque buildup.
• Anti-inflammatory Effects: Omega-3s play a crucial role in reducing inflammation throughout the body, which is beneficial for managing conditions like arthritis and other chronic inflammatory diseases.
• Cognitive Function: Omega-3s support brain health, improving cognitive function and reducing the risk of neurodegenerative diseases such as Alzheimer’s.
• Eye Health: Omega-3 fatty acids contribute to eye health by preventing macular degeneration and maintaining retinal function.
• Immune System Support: Omega-3s modulate the immune response, enhancing the body’s ability to fight infections and reducing the risk of autoimmune diseases.
• Skin Health: Omega-3s improve skin hydration, reduce inflammation, and contribute to healthier, more elastic skin.

OptiMSM (Methylsulfonylmethane)

The health benefits of Methylsulfonylmethane (MSM) as outlined in the research article by Butawan et al. (2017) 96 include:

• Anti-inflammatory Effects: MSM has been shown to reduce inflammation, which is beneficial for managing conditions like arthritis and other inflammatory diseases.
• Antioxidant Support: MSM enhances the body’s antioxidant capacity, helping to protect cells from oxidative stress and damage.
• Joint Health: MSM improves joint flexibility and reduces joint pain, contributing to better overall joint function.
• Exercise Recovery: MSM aids in reducing muscle soreness and damage after exercise, promoting faster recovery.
• Skin Health: MSM supports skin health by reducing inflammation and oxidative stress, leading to improved skin texture and elasticity.
• Immune System Support: MSM modulates the immune response, helping to maintain a balanced and effective immune function.
• Allergy Relief: Can alleviate symptoms of allergies by reducing histamine levels and inflammation97.